Getryl tablet composition, uses, side effects and drug interactions

Getryl 2mg tablet uses in diabetes


What is Getryl tablet?

Getryl is an antihyperglycemic medication that is taken orally and is used by doctors to lower blood glucose levels. Heart disease, damage to the nerves, damage to the kidneys, and issues with vision can all arise from untreated high blood glucose. Getryl is used to control high blood sugar in conjunction with a healthy diet and exercise. Additionally, it is used in conjunction with other medications.

Getryl tablet Composition: 

Getryl contains Glimepiride in tablet form. Glimepiride is an anti-diabetic that is used to treat diabetes type II in conjunction with strict diet and exercise. It stimulates the release of insulin from beta cells within the pancreas and takes approximately 2 to 3 hours to show its maximum effect. Getryl is used in conjunction with metformin to control high blood sugar when glimepiride and metformin are not controlling it sufficiently. It is used in conjunction with insulin to control high blood

Uses/Indication of Getryl tablet:

In patients with noninsulin-dependent (Type 2) diabetes mellitus (NIDDM) whose hyperglycemia cannot be controlled by diet and exercise alone as an addition to diet and exercise.

When diet, exercise, and GETRYL (Glimepiride) or metformin alone do not result in adequate glycemic control, it may be used in conjunction with metformin.

Additionally, it is recommended for use in conjunction with insulin to lower blood glucose levels in patients with hyperglycemia who are unable to control their condition through diet, exercise, or an oral hypoglycemic agent.

It can be used in conjunction with diet and exercise to control high blood sugar. It can also be used as a combination therapy to prevent diabetes complications like kidney disease and blindness. It takes about 2 to 3 hours for the drug to show its full effect. 

Getryl tablet available doses:

Getryl 1mg tablet

Getryl 2mg tablet

Getryl 3mg tablet

Getryl 4mg tablet

Getryl tablet uses and side effects
Getryl tablet available doses

Getryl tablet Side Effects 

People who take this medicine may experience the following:

Vision issues, nausea, vomiting, diarrhea, abdominal pain, and weight gain are all symptoms of hypoglycemia.

Most people tolerate glimepiride well. However, the following side effects have been reported during glimepiride treatment:

Hypoglycemia: sulfonylureas in general pose the greatest threat.

Reactions in the eye: The change in blood glucose levels may cause temporary visual impairment, such as changes in accommodation and/or blurred vision, particularly at the beginning of treatment.

Reactions to the GI tract: Occasionally, gastrointestinal symptoms like nausea, vomiting, epigastrium pressure or fullness, abdominal pain, and diarrhea may occur.

Reactions to the blood: Leukopenia and thrombocytopenia are rare but possible complications. Thrombocytopenic purpura, agranulocytosis, myelosuppression-caused pancytopenia, eosinophilia, hemolytic anemia, aplastic anemia, erythrocytopenia, and granulocytopenia may manifest in isolated instances.

Reactions on the skin: Patients taking sulfonylureas may occasionally experience allergic or pseudo-allergic skin reactions, such as pruritus, erythema, urticaria, erythematous, maculo-papular, bullous, or psoriasiform drug eruptions.

Reactions to the liver: Sulfonylureas have been associated in isolated cases with elevated bilirubin levels, abnormal liver function, cholestasis, cholestatic aernia, hepatitis, granulomatous hepatitis, and liver failure.

Disruption in Electrolytes: Patients taking glimepiride and other sulfonylureas have occasionally experienced hyponatremia. Most of the time, these patients are also taking other medications or have medical conditions that are known to increase antidiuretic hormone release or cause hyponatremia.

Others: With sulfonylureas, isolated cases of allergic vasculitis have been reported.

Warnings 

Pregnancy:

Uncertainty surrounds the medication's safety and efficacy during pregnancy. For further details, consult your doctor.

Nursing:

This medication's safety and efficacy in nursing women are unknown. For further information, talk to your prescriber.

Driving:

Driving shouldn't be done while taking this medication. Your ability to drive is affected by high or low blood sugar.

Liver Caution

Before using this drug, consult your doctor. Adjusting the dosage may be necessary.

Kidney Caution:

Before consuming this medication, talk to your prescriber. Adjusting the dosage may be necessary.

Alcohol 

Avoid drinking alcohol while taking this medication. Consuming alcohol may intensify Getryl's hypoglycemic effects.

Drug Interactions 

Certain drugs, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and other drugs that are highly protein-bound, such as salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, MAOIs, and beta-adrenergic blocking agents, may enhance the hypoglycemic effects of sulfonylureas. When these medications are given to a patient who is already taking glimepiride, the patient needs to be closely watched for hypoglycemia.

Hyperglycemia is a common side effect of some drugs, which can make it hard to control blood sugar. Oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, and isoniazid are among these medications. Patients receiving glimepiride should be closely monitored for loss of control after receiving these medications.

Cytochrome P-450 2C9 (CYP2C9) is responsible for the metabolism of glimepiride. When glimepiride is administered concurrently with CYP2C9 inducers, inhibitors, or substrates (such as rifampicin, fluconazole, amiodarone, tolbutamide, diclofenac, ibuprofen, or naproxen), this should be taken into consideration.

The blood-glucose-lowering effect of H2-receptor antagonists, -blockers, clonidine, and reserpine may either be enhanced or diminished.

The warning signs of a hypoglycemic attack may be obscured by treatment with a -receptor blocker, clonidine, guanethidine, or reserpine.

Consumption of alcoholic beverages both on a short-term and long-term basis may have an unpredictably varying effect on glimepiride's activity.

Getryl tablet Storage

Keep this medication out of the sun and heat in a cool, dry place.

How to Dispose of Getryl

Throw away this medication properly if it has expired or is no longer needed. 

FAQ 

Does this medication make you gain weight?

Yes, taking this medication or any other sulfonylurea may make you gain weight. If you're depressed regarding your weight, tell your doctor.

What should to do if I miss a dose?

If you have missed a dose, take it as soon as you remember to, unless your next dose is almost due, in which case skip the missed dose and resume your normal dosing schedule.

Is this medicine responsible for sunburn?

Glimepiride, which is found in Getryl, makes you more sensitive to the sun, increasing your risk of sunburn. Covering up and applying sunscreen before going outside are both preventative measures that can cut down on unnecessary exposure to the sun.

Is this medication safe for kids?

No, children under the age of 18 should not take this medication. Children may experience low blood sugar and weight gain as a result. Consult with your physician before giving any drug to your child.

How long must I take this medication?

Diabetes medications typically have a long-term effect because they control blood sugar levels but do not cure the condition.


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